• 0.5%/2.5% Cream

• Apply one pump (1g) of medication to the target area two times per day, morning and evening.

• Localized fat reduction from the waist and thighs.

• 2.5% / 0.06% / 0.5% Cream

• Apply one pump (1g) of medication to the target area two times per day, morning and evening

• Localized fat reduction from the waist and thighs  

During human aging, there is an increase in the activity of inflammatory, cancer-promoting, and tissue destructive genes plus a decrease in the activity of regenerative and reparative genes. The human blood tripeptide GHK possesses many positive effects but declines with age. It improves wound healing and tissue regeneration (skin, hair follicles, stomach, and intestinal linings, and boney tissue), increases collagen and glycosaminoglycans, stimulates the synthesis of decorin, increases angiogenesis, and nerve outgrowth, possesses antioxidant and anti-inflammatory effects, and increases cellular stemness and the secretion of trophic factors by mesenchymal stem cells. Recently, GHK has been found to reset genes of diseased cells from patients with cancer or COPD to a more healthy state. Cancer cells reset their programmed cell death system while COPD patients’ cells shut down destructive tissue genes and stimulate repair and remodeling activities.

Copper peptide GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L- lysine. The tripeptide has a strong affinity for copper(II) and was first isolated from human plasma.  The positive effects of GHK-Cu in the body decrease with age; thus, there is an increase in inflammation, harmful activity, and tissue destruction. In plasma, the level of GHK-Cu is about 200 ng/ml at age 20. By the age of 60, the level drops to 80 ng/ml.

GHK was discovered during studies comparing the effect of human plasma from young persons (age 20–25) to plasma from older persons (age 50–70) on the functioning of incubated slices of human hepatic tissue. The younger plasma more effectively induced a profile associated with youth by suppressing fibrinogen synthesis. The active factor was found to be GHK.

Developing and testing GHK-based products for internal use to support the health of elderly populations and as a complementary therapy in cancer treatment is one possible direction for future research. Based on both biological and gene data, GHK also has the potential to be developed into an anti-anxiety and anti-pain supplemental treatment, and it may be an essential component in a future complex approach to COPD therapy.

Neurodegeneration, the progressive death of neurons, loss of brain function, and cognitive decline is increasing problem for senior populations. Its causes are poorly understood, and therapies are largely ineffective. Neurons with high energy and oxygen requirements are especially vulnerable to detrimental factors, including age-related dysregulation of biochemical pathways caused by altered expression of multiple genes. GHK (glycyl-l-histidyl-l-lysine) is a human copper-binding peptide with biological actions that appear to counter aging-associated diseases and conditions.

This medication:

• Improves wound healing and tissue regeneration (skin, hair follicles, bones, stomach, intestinal linings, and liver)

• Increases collagen and glycosaminoglycans

• Stimulates the synthesis of decorin

• Increases angiogenesis, and nerve outgrowth

• Possesses antioxidant and anti-inflammatory effects

• Increases cellular stemness and the secretion of trophic factors by mesenchymal stem cells [3–6].

The Suppression of Fibrinogen Synthesis. Fibrinogen is an excellent predictor of mortality especially in patients with cardiovascular complications. GHK was isolated as a plasma factor that suppressed fibrinogen synthesis in liver tissue.

Activation of the Ubiquitin/Proteasome System (UPS). The UPS removes damaged proteins. Higher activities of the UPS appear to retard aging effects.

Activation of DNA Repair Genes. DNA damage is promptly repaired in young and healthy cells, however, as we age, DNA damage starts accumulating. Resetting the activity of DNA repair genes can diminish the deleterious effects of aging.

Antioxidant Genes. Free radicals and toxic end products of lipid peroxidation are linked to atherosclerosis, cancer, cataracts, diabetes, nephropathy, Alzheimer’s disease, and other severe pathological conditions of aging.

Suppression of Insulin and Insulin-Like Genes. The insulin family has been proposed as a negative controller of longevity; higher levels of insulin and insulin-like proteins reduce the lifespan.

Tissue Repair by TGF Superfamily. General tissue repair by the TGF superfamily as exemplified by COPD (chronic obstructive pulmonary disease).

Cancer Controlling Genes. Caspase, growth regulatory, and DNA repair genes are important in cancer suppression.

Reconstitute with 6mL bacteriostatic water inject 20 units (0.2mL) SQ daily.

Further Reading:

The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline.

GHK and DNA: Resetting the Human Genome to Health

• 3%/0.3%/0.2%/0.5%/1.5% Cream

• Apply one pump of medication to the face and neck two times per day, morning and evening

• Improves skin moisture

• Decreases wrinkle depth and pore size

• Mitigation of forehead lines and periorbital fine wrinkles

• Improving lip shale and fullness as well as overall appearance of aging skin

• Beneficial trends were noted in the appearance of coarse wrinkles, under-eye dark circles, nasolabial folds, sagging neck skin, and neck firmness.

In recent years, peptides have gained significant attention in the fields of health, wellness, and biomedical research. Among these, the FG Loop FGL peptide stands out due to its promising benefits.

What is FG Loop FGL Peptide?

• FG Loop FGL peptide is a synthetic peptide derived from a sequence within the neural cell adhesion molecule (NCAM). It has been extensively studied for its potential to enhance cognitive functions and support neural health. This peptide mimics the action of natural molecules in the brain, contributing to various beneficial effects on brain function and overall health.

Five Key Benefits of FG Loop FGL Peptide

1. Enhanced Cognitive Function FG Loop FGL peptide is known for its ability to enhance cognitive functions such as memory, learning, and focus. By promoting synaptic plasticity and neurogenesis, it supports the brain’s ability to form and retain new connections, which is crucial for learning and memory retention.

2. Neuroprotection One of the significant benefits of FG Loop FGL peptide is its neuroprotective properties. It helps protect neurons from damage and degeneration, which can be particularly beneficial in conditions like Alzheimer’s disease and other neurodegenerative disorders. This peptide aids in maintaining the integrity of neural circuits, thus supporting overall brain health.

3. Mood Regulation FG Loop FGL peptide has shown potential in regulating mood and reducing symptoms of anxiety and depression. By modulating neurotransmitter levels and promoting neural health, it can contribute to a more balanced and positive mood.

4. Enhanced Recovery from Neural Injuries For individuals recovering from neural injuries, FG Loop FGL peptide can be highly beneficial. It aids in the regeneration of neural tissues and supports the recovery process, potentially improving outcomes for patients with traumatic brain injuries or stroke.

5. Support for Neuroplasticity, the brain’s ability to reorganize itself by forming new neural connections, is vital for adapting to new experiences and learning new skills. FG Loop FGL peptide enhances neuroplasticity, making it an excellent supplement for individuals seeking to improve their cognitive abilities and overall brain function.

FG Loop FGL peptide can be beneficial for a variety of individuals, including:

• Students and Professionals: Those seeking to enhance their cognitive abilities, memory, and focus can benefit from this peptide. It can help in improving academic performance and productivity.

• Older Adults: As cognitive decline is a natural part of aging, older adults looking to maintain or enhance their cognitive functions may find this peptide helpful.

• Individuals with Neurodegenerative Conditions: Patients suffering from conditions like Alzheimer’s disease or Parkinson’s disease might benefit from the neuroprotective and neuroregenerative properties of FG Loop FGL peptide.

• People with Mood Disorders: Those experiencing anxiety, depression, or other mood disorders may find relief through the mood-regulating effects of this peptide.

• Athletes and Rehabilitation Patients: Athletes or individuals recovering from neural injuries might use this peptide to support neural recovery and enhance brain function.

Instill one spray in each nostril daily, five out seven days per week.

• 0.2%/0.5%/3% Serum

• Apply one pump of medication to the forehead and face two times daily. Morning and Night. Apply to clean dry skin.

• Relaxes facial muscles 

• Reduces expression of wrinkles 

• Protects against the development of new facial wrinkles 

• 0.2%/0.5%/0.5% Cream

• Apply one pump of medication to the forehead and face two times daily. Morning and Night. Apply to clean dry skin.

• Relaxes facial muscles 

• Reduces expression of wrinkles 

• Protects against the development of new facial wrinkles 

Anti-Wrinkle Rejuvenation Serum

In clinical studies, the formation of facial wrinkles has been closely linked to the loss of elastic properties of the skin. Cumulative irradiation with ultraviolet (UV) B at suberythemal doses significantly reduces the elastic properties of the skin, resulting in the formation of wrinkles.

Peptides of synthesis are a very new strategy in cosmetic science and technology for at least two reasons: (1) they are small molecules, easily penetrable in the skin and (2) they are able to induce a very specific action because all skin cells (keratinocytes, fibroblasts, nervous cells) have membrane receptors for peptides. This group of cosmeceuticals includes the Botox-like peptides, represented by acetyl hexapeptide 3 (Argireline) and pentapeptid-3 (Leuphasyl).

This substance inhibits the neuromuscular synapses in the mimic muscles, acting as enkephalins. It links the enkephalin receptor to nerve cells, thereby modulating the release of acetylcholine in synaptic space.  This cellular activity will be translated in vivo in a relaxation of the muscle and a reduction of expression wrinkles.

Argireline, a mimetic of Botox, has been found to be safer than Botox and effective in reducing wrinkles, with efficacy up to 48% upon 4 weeks of twice-daily treatment.

Argireline, a synthetic peptide, which is patterned from the N-terminal end of the protein SNAP-25, can both reduce the degree of existing facial wrinkles and demonstrate effectively against their development.

GHK-Cu is a naturally occurring copper complex that was first identified in human plasma. Copper peptides are small, naturally occurring protein fragments that have a high affinity for copper ions, which are critical to normal body function.  It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. It then plays a significant role in signaling tissue remodeling, which removes damaged/scarred tissue and generates new, healthy tissue. However, these positive effects decline with age because the concentration of GHK-Cu in the body decreases with age.

Atrophic Crinkling Rhytids: fine lines on the face that are almost parallel to each other. They show up on different areas of the face and body but tend to disappear when the skin is stretched transversally (this just means they shift when your body posture changes). These wrinkles are associated with loss of elasticity (loss of collagen).

Permanent Elastic Creases: Crease lines in the skin that become increasingly permanent over time, especially with sun exposure. They show up most frequently on the cheeks, the upper lip and the base of the neck. Sun exposure and also smoking are involved in the extension of those wrinkles.

Dynamic Expression Lines: Wrinkles that are caused by facial muscle movement. Most of the facial muscles have involuntary movements. In this case, the wrinkles’ form is perpendicular to the long axis of the muscle. The relaxation of the muscles over which the skin is pulled can improve those wrinkles.

Gravitational Folds: The name implies, these lines are due to the effects of gravity and become increasingly obvious as the skin begins to fold and sag. The location of these wrinkles is related to the thickness of the skin.

Unleash the power of peptides to help:

• Tighten loose skin and reverse thinning of aged skin.

• Repair protective skin barrier proteins.

• Improve skin firmness, elasticity, and clarity.

• Reduce fine lines, depth of wrinkles, and improve the structure of aged skin

• Smooth rough skin.

• Reduce photodamage, mottled hyperpigmentation, skin spots, and lesions.

• Improve overall skin appearance.

• Stimulate wound healing.

• Protect skin cells from UV radiation.

• Reduce inflammation and free radical damage.

Apply one pump to clean dry skin topically to the forehead and face two times daily in AM and PM

Further Reading:

The Anti-Wrinkle Efficacy of Argireline, a Synthetic Hexapeptide

Enhanced Skin Permeation of Anti-wrinkle Peptides via Molecular Modification

The Efficiency and Safety of Leuphasyl—A Botox-Like Peptide

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

Key Benefits of Macimorelin:

• Non-Invasive & Easy-to-Administer: No painful injections, just a simple oral dose

• Increased GH Production: Macimorelin triggers a significant increase in GH secretion, promoting various physiological processes.

• GH Release Profile: It induces a pulsatile GH release pattern resembling natural GH secretion.

• Sarcopenia: Macimorelin has the potential to address sarcopenia and age-related muscle loss, improving muscle strength, function, and overall quality of life.

• Pituitary Insufficiency: Macimorelin may be beneficial for patients with GH deficiency, improving pituitary function and restoring hormone balance.

• Metabolic Disorders: It may be helpful in managing metabolic disorders like obesity, type 2 diabetes, and metabolic syndrome, promoting weight loss and improving glucose control.

• Cardiovascular Health: Emerging evidence suggests that Macimorelin may have beneficial effects on cardiovascular health, including improved heart function and blood pressure regulation.

• Fracture Healing: GH promotes bone healing, making Macimorelin a potential therapeutic agent for patients with fractures, particularly in the elderly.

Who Might Benefit?

• Individuals with GH Deficiency & Obesity: If GH deficiency contributes to excess fat retention, short-term Macimorelin use could help.

• People on GLP-1 Medications Who Experience Muscle Loss: Increasing GH temporarily could help preserve lean mass if muscle loss is a concern.

• Athletes Exploring GH Optimization: Some fitness enthusiasts seek GH stimulation for muscle growth.

Take one capsule by mouth daily in the morning. For best results, take it after 8 hours fasted. Do not spike insulin 2 hours after taking the medication. It has a four-hour half-life.

You should avoid spiking insulin while taking Macimorelin because insulin can suppress growth hormone (GH) secretion.

• 10mg Vial

• Reconstitute with 5mL's of BAC water and inject 15 units (300mcg)
  SQ daily for the first 1-2 weeks. Weeks 2+ inject 25 units (500mcg) a week after for maintenance. Adjust accordingly to pigment changes.

• Supports Melanogenesis

• Tanning

• Photo-protection from UV rays and increased protection from melanoma.

• 5mg / 10mg / 15mg Capsules

• Take one capsule by mouth daily. 

• Enhanced Cognitive Function

• Increased Energy Levels

• Improved Mood and Emotional Well-being

• Enhanced Metabolism and Weight Management

• Powerful Antioxidant and Anti-inflammatory Effects

• 1,000mg Vial

• Reconstitute with 5mL’s of BAC water and inject 50units (100mg) SQ 2-3 times per week.

• Promotes cognitive and sensory function 

• Restores cellular energy, mitochondrial dysfunction 

• Autoimmune Diseases 

• Depression and anxiety 

• Drug addiction and Detox 

• Recovery from injury 

• Protects against cardio- and cerebrovascular disease 

Low dose naltrexone (sometimes combined with buproprion and can be obtained at a retail pharmacy often with insurance coverage)

• Naltrexone, typically used to treat opioid and alcohol use disorders, has shown promise as a weight loss treatment in conjunction with lifestyle changes when prescribed in lower doses or with other drugs.

• In clinical studies, the combination of naltrexone and bupropion, known as Contrave, resulted in significant weight loss over 52 to 56 weeks compared to a placebo with minimal side effects.

• Naltrexone may work for weight loss by affecting brain areas that regulate appetite and metabolism. It potentially reduces the desire to overeat and impacts hormones like ghrelin and leptin.

• Suitable candidates for naltrexone for weight loss include individuals who are overweight or obese, not physically dependent on opioids and have not succeeded in losing weight through diet and exercise alone.

• Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome.

Further Reading:

The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain - PMC

Low Dose Naltrexone for Pain Management

The effects of bupropion alone and combined with naltrexone on weight loss

• 15mg Vial

• Reconstitute with 7.5 mL's of BAC water and inject 25units (500mcg) daily in the AM.

• Tendon healing

• Decrease pain

• Increase collagen synthesis.

• Quicker recovery times post-injury.

• Wound and bone healing

• Decrease inflammation

• Intestinal issues.

• Protects the heart

• Reverse opioid tolerance

• Enhance GABA neurotransmisson

• 500mcg / 1000mcg Capsules

• Take one capsule by mouth daily.

• Tendon healing.

• Decrease pain.

• Increase collagen synthesis.

• Quicker recovery times post-injury.

• Wound and bone healing

• Decrease inflammation

• Intestinal issues

• Protects the heart

• Reverse opioid tolerance

• Enhance GABA neurotransmisson

• Regulation of Sleep Patterns

• Enhancement of Cognitive Functions

• Antioxidant Properties

• Support in Cellular Repair

• 20mg Vial

• Reconstitute with 2 mL's of BAC water. Inject 20 units (2mg). First dose start with 10-15 units 1-1.5mg to access tolerance. DO NOT EXCEED 20 units 2 mg IN 72 HOURS. Dose 2x weekly initially, then increase if tolerated.

• Increase sexual frequency.

• Boost sex drive

• Treatment for men and women with hypoactive sexual desire
  disorder.

• Raise sexual desire

• Increase female sexual function index total score and
  female sexual distress scale-desire/arousal/orgasm total
  score

• 7.5mg/mL Nasal Spray. 3mL and 1mL Vials

• Instill one spray in each nostril 1 to 4 hours before sexual activity. DO NOT EXCEED FOUR SPRAYS (2mg) IN 72 HOURS

• Increase sexual frequency.

• Boost sex drive.

• Treatment for men and women with hypoactive sexual desire
  disorder.

• Raise sexual desire

• Increase female sexual function index total score and
  female sexual distress scale-desire/arousal/orgasm total
  score

• 15mg Vial

• Reconstitute with 3mL bacteriostatic water inject 10 units (0.10mL) SQ daily 2x per day AM and PM before bed. No spiking insulin 2 hours before or 30 minutes after injection

• Improvements in well-being and libido.

• Augmented restful sleep leads to better cognitive functions.

• Refined skin tone with stronger hair and nails. 

• Decrease in mean systolic blood pressure.

• Improvement in fat loss and lean mass gains

• Increased endurance and strength.

• Significant increases in GH release two hours after administration.

• Elevated mean 24-h GH, peak GH amplitude, and GH area under the peaks. 

• 50mg/mL 6mL Vial

• Inject 20 units (0.2mL) SQ Daily

• Amyotrophic Lateral Sclerosis (ALS).

• Alzheimer's Disease

• Glaucoma

• Diabetes

• Skeletal muscle weakness

• Traumatic brain injury

• Atherosclerosis

• Heart Failure with Ischemia-Reperfusion

• Kidney fibrosis

• Friedreich ataxia

• 2 / 50 mg/mL 15 mL Vial Nasal Spray
  2 / 50 mg/mL 30 mL Vial Nasal Spray

• Instill two sprays in each nostril daily.

• Memory improvement

• Decrease brain toxicity and inflammation.

• Support of neurological and cognitive health

• Mental acuity enhancement

• Brain cellular energy production

• Traumatic brain injury

• Stroke

• Post concussion syndrome

• 5mg / 6mg capsules

• Take one capsule by mouth weekly

• Anti-Aging Effects

• Anti-Cancer Properties

• Treatment of Autoimmune Diseases

• Treatment of Alzheimer's Disease

• Treatment of Metabolic Disorders

• Tesofensine is a triple reuptake inhibitor that increases the levels of three neurotransmitters in

• the brain: Serotonin, norepinephrine, and dopamine.

• Tesofensine causes a significant increase in weight loss and fat loss by reducing appetite,

• increasing resting energy expenditure (ie increasing metabolism and calories burned),

• increasing fat oxidation, and reducing fat tissue.

• Tesofensine is an effective weight-loss medication. Studies have shown more weight loss with

• higher tesofensine doses up to 1 mg. A clinical study found that participants receiving

• tesofensine at doses of 0.25 mg, 0.5 mg, and 1.0 mg in conjunction with a prescribed diet for 6

• months had a mean weight loss of 4.5%, 9.2%, and 10.6%. Comparatively, patients in this

• study treated with a placebo only lost an average of 2% of their body weight. There was a 4-

• point drop in BMI in a period of 24 weeks in those treated with 0.5 mg and 1 mg.

• Tesofensine has been shown to have a good safety profile and was well tolerated although an

• increased number of adverse events (e.g., increased heart rate and blood pressure) were

• observed in the higher dose groups of 0.5 mg and 1.0 mg. Blood pressure and heart rate were

• increased by 1–3 mmHg and up to 8 bpm, respectively. Other side effects of Tesofensine may

• include dry mouth, headache, nausea, insomnia, diarrhea, and constipation. Side effects are

• dose-dependent and are more significant when using higher doses.

• The tesofensine dosage range used in studies was 0.25 mg to 1 mg. The weight loss of 9.2%

• in the 0.5 mg tesofensine dose vs 10.6% in those using the 1 mg tesofensine dose may not

• justify the dose-dependent increases in side effects. Based on this, the best tesofensine dose

• for most patients would be 0.5 mg or lower.

Studies and Further Reading

• Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons - PMC

• Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial - PubMed

• 200/40mg capsule

• Take one capsule by mouth three times per day. 

• Weight loss

• Decrease LDL Cholesterol 

• Improve insulin resistance

• Decreased the epididymal adipose (fat) tissue mass

• Increase fatty acid transport, uptake, and oxidation

• Lower blood pressure

• Reduction in Hemoglobin A1c and fructosamine

• Cardioprotective

• 15mg Vial

• Reconstitute with 2mL's of BAC water and Inject 50 units (3.75mg) SQ weekly.

• Up-regulates Actin and forms a ternary complex with
  actin and profilin.

• Increased cells in healing

• Improves cell migration to the cite of the injury

• Soft tissue repair - tendon, ligament, muscle sports,
  and athletic injuries

• Reduces scar tissue

• Significant repair and regenerative properties.

• Enlarged muscle growth, muscle tone, and muscular
  stamina.
  
  

• 15mg Vial

• Reconstitute with 3mL's of BAC water and inject 10 units (500mcg) SQ daily.

• Immune strengthening.

• Immune modulator.

• Normalization of T-helper cells to suppressor cells.

• Downregulates the release of inflammatory mediators, such as cytokines and chemokines.

• Upregulates anti-inflammatory factors, such as interleukin (IL)-10.

• 500mcg/mL 12mL Nasal Spray

• Instill two sprays into each nostril daily.

• Mold toxicity and other biotoxin illnesses

• Regulates smooth muscle activity and blood flow in the GI tract

• Anti-inflammatory effects

• Helps healing activity of the brain