Supplemental Weight Loss

  • Low dose naltrexone (sometimes combined with buproprion and can be obtained at a retail pharmacy often with insurance coverage)

    • Naltrexone, typically used to treat opioid and alcohol use disorders, has shown promise as a weight loss treatment in conjunction with lifestyle changes when prescribed in lower doses or with other drugs.

    • In clinical studies, the combination of naltrexone and bupropion, known as Contrave, resulted in significant weight loss over 52 to 56 weeks compared to a placebo with minimal side effects.

    • Naltrexone may work for weight loss by affecting brain areas that regulate appetite and metabolism. It potentially reduces the desire to overeat and impacts hormones like ghrelin and leptin.

    • Suitable candidates for naltrexone for weight loss include individuals who are overweight or obese, not physically dependent on opioids and have not succeeded in losing weight through diet and exercise alone.

    • Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome.

    Further Reading:

    The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain

    Low Dose Naltrexone for Pain

    The effects of bupropion alone and combined with naltrexone on weight loss

  • 30 Grams Cream

    The fat on the thighs and abdominal area is more difficult to mobilize due to increased alpha-2 adrenergic receptor activity induced by estrogen. Lipolysis can be initiated through adipocyte receptor stimulation (beta-adrenergic) or inhibition (adenosine or alpha-2 adrenergic) or by inhibition of phosphodiesterase. Since many people desire regional thigh and abdominal fat loss, Topical aminophylline abdominal and thigh cream has been introduced as a method of treating cellulite, or dimpled thighs and buttocks.

    Cortisol is involved in the distribution and deposition of fat, and its action is regulated by the activity of 11beta-hydroxysteroid dehydrogenase. Glycyrrhetinic acid, the active principle of licorice root, blocks 11beta-hydroxysteroid dehydrogenase type 1, thus reducing the availability of cortisol at the level of adipocytes.

    These two products together work as an excellent addition to help with localized fat reduction in those areas where patients are having difficulty losing those last couple of inches.

    For patients to achieve the best results, they would want to apply this cream to the target fat reduction areas two times per day morning and night.

    Further Reading:

    Topical fat reduction from the waist.

    Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application.

  • Nicotinamide-N-methyltransferase (NNMT), is a cytosolic enzyme with newly identified roles in cellular metabolism and energy homeostasis. Studies indicate that this enzyme slows down the process at which our bodies metabolize fat cells. Most people have a hard time losing weight, and when this enzyme is elevated, they have a more challenging time trying to lose excess pounds of fat. The extra weight leads to an increase in the NNMT enzyme, leading to slower fat metabolism, leading to excess weight gain. It is a vicious cycle. Research suggests a potent NNMT inhibitor "5-amino-1mq" significantly reduced body weight and white adipose mass decreased adipocyte size and lowered plasma total cholesterol levels.

    These results support the development of small molecule NNMT inhibitors as therapeutics to reverse diet-induced obesity and validate NNMT as a viable target to treat obesity and related metabolic conditions.

    Benefits:

    • NNMT inhibitors as therapeutics to reverse diet-induced obesity.

    • NNMT is a viable target to treat obesity and related metabolic conditions.

    • Prevent adipogenesis and reverse diet-induced obesity.

    • NNMT expression is up-regulated in the white adipose tissue (WAT). It has significantly higher activity in the WAT than its activity in the brown adipose tissue, liver, and lungs.

    • NNMT inhibitors did not impact food intake. Still, it produced marked reductions in body weight, WAT mass, adipocyte size, and cholesterol levels with negligible toxicity or observable adverse effects.

    Take one - three capsules by mouth daily

    Further Reading:

    Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity